The positive correlation between vitamin D and HDLC can be also partly attributed to the impact of vitamin D on HDL apolipoproteins; in interventional studies, an increase in apolipoprotein A1 levels has been observed after vitamin D supplementation, which might be the result of apolipoprotein A1 gene transcription enhancement in human hepatoma cells [48]. This evidence concerns the gene APOA1 and hepatocellular carcinoma.