Regarding cardiometabolic indices, compared to MetS-free participants, those with MetS exhibited higher BMI, WC, obesity rates, SBP, DBP, fasting glucose, insulin, HOMA-IR, TG, and hsCRP, and lower HDLC and adiponectin (all P < 0.050). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.