Our recent published work showed that anti-CFH autoantibodies were positive in 8.3% of LN patients, patients with anti-CFH autoantibodies presented with milder renal damage, and the purified autoantibodies could enhance the C3b binding and CFI cofactor activity of CFH in vitro, which suggested a protective role in the lupus nephritis [16]. The gene discussed is C3; the disease is lupus nephritis.