Importantly, we found that immunization with hCFH and subsequent development of anti-CFH autoantibodies significantly attenuated glomerulonephritis on pristane-induced lupus nephritis, like decreased levels of proteinuria and lower serum creatinine value, lower levels of serum anti-dsDNA antibody, greatly ameliorated renal histopathologic damage and decreased IgG, complements and some inflammatory factors deposits in glomerulus. The gene discussed is CFH; the disease is lupus nephritis.