Genetically driven higher production of uromodulin becomes deleterious over time, promoting the onset of CKD [44].In some genome-wide association studies(GWAS), the UMOD alleles associated with higher uromodulin expression/levels are associated with increased risk of CKD, hypertension, and hyperuricemia, whereas they are protective against kidney stones [38, 45],indicating it’s importance for a set of common diseases. This evidence concerns the gene UMOD and nephrolithiasis.