COL1A1 and neoplasm: As predicted, all three kinds of CAFs showed active EMT, as indicated by strong metalloprotease (MMP2, MMP14, MMP11) and collagen (COL10A1, COL11A1, COL5A1, COL1A1, COL27A1) production, allowing them to breakdown the extracellular matrix and leave the initial tumor location to metastasize.