In the present study, despite the presence of equivalent vaccine-induced, antibody-binding titers, we observed divergent vaccine-induced, FcR-binding antibody profiles, marked by enhanced and preferential FcγR3B binding in individuals who did not develop COVID-19, compared with elevated inflammatory isotypes/subclass/FcR antibody-binding profiles (IgA and IgG3) in vaccinees who ultimately developed COVID-19. This evidence concerns the gene IGHG3 and COVID-19.