Importantly, all FcγR3B features were linked to each other (Fig. 3e), suggesting that vaccinees who did not develop COVID-19 for the duration of the study elicited a highly coordinated broad FcγR3B-binding response across both RBD and S. Conversely, three separate networks emerged linked to the markers enriched in vaccinees who developed COVID-19, including small networks of FcγR2B WT S, WT RBD and beta VOC RBD features, and a more extensive network of IgG1, FcR2A, FcγR3A WT and beta VOC features. Here, FCGR3B is linked to COVID-19.