Moreover, correlational analysis of the WT- and VOC-induced humoral immune responses across vaccinees who did not develop COVID-19 pointed to a negative correlation between FcγR2B-binding antibodies and IgA and IgM responses (Fig. 4b), but more diffuse coordination of all FcR-binding profiles with isotype selection in individuals who were ultimately infected (Fig. 4c). This evidence concerns the gene CD79A and COVID-19.