CD4 and inflammatory bowel disease: There was no increase in IL-17A+FOXP3−, FOXP3+IL-17−, IFNγ+FOXP3− or TNFα+FOXP3− CD4 T cells, nor an increase in IFNγ+FOXP3+ or TNFα+FOXP3+ DP cells in PSC I2 compared to IBD I2 (Extended Data Fig. 2e–j).