STUB1 and Alzheimer disease: One- and two-sample MR using 24 CHIP-associated polymorphisms18 as the instruments (Supplementary Table 7) found that higher genetic risk of CHIP was associated with reduced odds of AD using the weighted median estimator (OR = 0.90 per 1 log-odds increase in risk of CHIP, P = 3.3 × 10−4, Fig. 2c).