Pulldowns using a lysate of the colorectal cancer cell line SW620 showed clear dose-dependent competition of HDAC1, HDAC2 (including co-competed members of the HDAC1/2 containing CoREST complex), and HDAC6 for both (R/S)-LA and (R/S)-LM with affinities in the range of 3–33 μM (Fig. 1c, Supplementary Fig. 1a, Supplementary Data 1). Here, HDAC6 is linked to colorectal cancer.