To determine whether CNK2 and SAMD12 are involved in tumour growth and metastasis, we injected luciferase-expressing 143B control (empty vector), CNKSR2KO, or SAMD12KO cells intravenously through the tail vein of immunodeficient mice and monitored tumour development through bioluminescence imaging at weekly intervals for 3 weeks. Here, SAMD12 is linked to neoplasm.