USP33 could inhibit docetaxel-induced apoptosis of prostate cancer cells, including androgen-independent prostate cancer cells, mechanistically, USP33 could inhibit the Lys48 (K48)-linked polyubiquitination of DUSP1 which led to impaired JNK activation and apoptosis in prostate cancer [19]. This evidence concerns the gene MAPK8 and prostate cancer.