Skeletal muscle, similar to visceral adipose tissue, regulates blood glucose homeostasis, and it is responsible for absorbing 80% of postprandial glucose from the circulation; GLUT4 is a key protein that is involved in glucose transport into skeletal muscle.117 According to an analysis in a previous study, periodontitis-derived virulence factors mainly cause skeletal muscle IR by activating the immune inflammatory response of the body and disrupting the secretion of adipokines, leading to the abnormal function of GLUT4. Here, SLC2A4 is linked to periodontitis.