Of the Kv channels, Kv7.2 and Kv7.3 were particularly interesting because they represent principle subunits of Kv7/KCNQ channels, which are known to regulate neuronal excitability24–27 and have been implicated in ASD2,28,29 and epilepsy30. This evidence concerns the gene KCNQ3 and atrial septal defect 2.