ANK2 and Anxiety: Analyses of global Ank2 heterozygous KO mice (Ank2+/– mice; male), derived from Ank2fl/fl mice (see Methods for details), using a battery of behavioral tests revealed that their behaviors were largely normal, compared with wild-type (WT) mice, in domains including locomotion, anxiety-like behavior, social interaction, repetitive behavior, learning and memory (spatial and fear), motor coordination, and sensory-motor behavior (Supplementary Fig. 2).