Different clinical, fluid, and imaging biomarkers of AD severity were found to be associated with progressive tau deposition in subsequent Braak stages or a stronger signal in Braak ROIs: cognitive decline (11,17,22–24,26,27,33), dementia severity (17,26), amyloid positivity or load (11,17–19,22–24,26), CSF measures (22,26), plasma phosphorylated tau (26), diminished hippocampal volume (11,17,18,23), and cortical atrophy (31). Here, MAPT is linked to Mental deterioration.