Because IL-22R1, which determines the receptor specificity for IL-22, is expressed in non-immune cells including epithelial cells, fibroblasts, endothelial cells [11–13], and cardiomyocytes [17], endogenous IL-22 would exert its cardioprotective effect through the function of these cell types after MI. The gene discussed is IL22RA1; the disease is myocardial infarction.