Raised peripheral cytokines and chemokines (inter-leukin-1β [IL-1β], IL6, C-reactive protein [CRP], tumor necrosis factor-α [TNFα], CXCR3, and CXCL10) due to rheumatoid arthritis might change the immune status and function of the central nervous system via humoral and neuronal routes of communication [31]. This evidence concerns the gene TNF and rheumatoid arthritis.