Although not significant, long-term stimulation with of SufR showed higher frequencies of CD4+IFNg+IL2+IL10-TNFa- multifunctional T cells in active TB group when compared to QFN neg (p = 0.15) and QFN pos (p = 0.021) group, while short term stimulation showed higher frequencies in CD4+IFNg-IL2+IL10-TNFa- subset in QFN neg group when compared to QFN pos (p = 0.05) group. This evidence concerns the gene CD4 and tuberculosis.