As multiple immunologic stimuli are known to converge on the NF kappaB pathway and as the GSEA analysis implied that this pathway was induced upon infection (Figure 2—figure supplement 4), we assessed NF kappaB signaling by generating reporter mice in which five tandem repeats of a canonical NF kappaB response element were inserted upstream of a minimal promoter to drive expression of a nuclear localized and 3xHA epitope-tagged tandem dimer Tomato from the Rosa26 locus (nls-tdT-3xHA; Figure 6C). This evidence concerns the gene DNTT and infection.