However, for most transcripts that exhibit abundances changes with infection, those changes were limited to smaller subsets of cell types, for example, the down-regulation of Col14a1, Col8a1, and Slc4a10 in dural fibroblasts, the down-regulation of Igsf8, Tmtc4, and Zfp536 in arachnoid and pial fibroblasts and arachnoid barrier cells, and the up-regulation of Cxcl2 in macrophages (Figure 2—figure supplement 3A and B). Here, IGSF8 is linked to infection.