Although the relative abundances of the principal meningeal cell types did not change with infection, as judged by counting nuclei in the five snRNAseq libraries (Figure 3D upper panel), parsing the individual immune cell types revealed an ~twofold decrease in the abundance of CCL2- resident macrophages, a > 10-fold increase in inflammatory macrophages (IL1R1+ and IL1R1-), and a several-fold increase in the abundance of monocytes or monocyte-derived cells (Figure 3D, lower panel). The gene discussed is IL1R1; the disease is infection.