Multiple transcriptome changes distinguish the infection responses of different EC clusters, including down-regulation of transcripts coding for amino acid transporters SLC7A1 and SLC7A5 in leptomeningeal ECs and down-regulation of transcripts coding for plasmalemma vesicle associated protein (PLVAP; a marker of high permeability vasculature) and the mechanosensory channel PIEZO2 in dural ECs (Figure 4C–E). This evidence concerns the gene PIEZO2 and infection.