ERBB2 and breast cancer: Denkert, et al reported that intratumoral TILs were a significant and independent predictive biomarker for pCR in 2 independent cohorts.1,50 Khoury et al also reported that both stromal and intratumoral TILs were independent predictors for pCR in TNBC, whereas only intratumoral TILs significantly predicted pCR in ER-positive/HER2-negative subtype breast cancer.5 Neither study showed significance in the HER2-positive subtype.