EBV+ NPC WHO 2 and 3 is a homogenous cancer driven largely by NF-kB signaling caused by somatic aberrations of negative regulators including LMP1, CYLD, TRAF, and NFKBIA or overexpression of EBV oncoproteins [12, 13]. The gene discussed is PDLIM7; the disease is nasopharyngeal carcinoma.