Panel sequencing identified a single MSH6 somatic mutation (NM_000179.2: c.1135_1139del p.Arg379*) at a variant allele frequency (VAF) of 10.1% in the EC and two MSH6 somatic mutations (c.3261del p.Phe1088Serfs*2 and c.1135_1139del p.Arg379*) in the CRC at VAFs of 23% and 18.6%, respectively. Here, MSH6 is linked to colorectal carcinoma.