PBPK model simulations of folate intake together with [68Ga]Ga-PSMA-11 (t = 0) showed clinically relevant decreases in salivary glands and kidney uptake only with high folate doses (5 and 10 mg), while effects of folate on tumor uptake were not clinically relevant for all simulated doses. This evidence concerns the gene FOLH1 and neoplasm.