Predictions using our final PBPK model showed that co-administration of high doses folate (5 and 10 mg folic acid) with [68Ga]Ga-PSMA-11 showed clinically relevant decreased uptake in salivary glands (34% and 36% for 5 and 10 mg, respectively) and kidney (32% and 34% for 5 and 10 mg, respectively) for patients with PCa. The gene discussed is FOLH1; the disease is posterior cortical atrophy.