AURKB and intrahepatic cholangiocarcinoma: It was demonstrated that AURKB could influence mRNA and protein expression levels of EMT markers in ICC cell lines through in vitro. EMT is induced by a variety of signaling pathways, by screening these EMT-related signaling pathways, we found that AURKB overexpression or knockdown significantly affected the protein and mRNA levels of PI3K/AKT signaling.