The IFNγ/IL4 ratio was significantly lower in POAG in comparison with both, HC and OHT (POAG: median 52.41, 40.81–68.53 (pg/ml), OHT: median 82.26, 61.47–88.2 (pg/ml), p < 0.02, HC: median 100, 78.94–159.8 (pg/ml), p < 0.001, please see Fig. 2). The gene discussed is IFNG; the disease is open-angle glaucoma.