Finally, for further verification of the mechanism of disulfidptosis, pharmacological inhibition of glucose uptake with glucose transporter (GLUT) inhibitors were used in SLC7A11-overexpressing tumor cells, and the results demonstrated the same cytotoxicity as glucose starvation, accompanied by excessive disulfide formation in actin cytoskeleton and F-actin collapse. This evidence concerns the gene SLC2A1 and neoplasm.