TP53 and renal fibrosis: In the study of renal fibrosis, SERPINE1 also appears to up-regulate renal p53, since p53 protein levels are increased by sustained renal SERPINE1 expression and p53 stable suppression in SERPINE1 transductants, attenuating the induction of fibrotic factors, reversing the proliferative defects, and reducing the susceptibility to cell death.