SERPINE1 is a reliable biological and prognostic marker for a variety of cancers, including breast (Feng et al. 2020), pancreatic (Yu et al. xxxx), bladder, colon (Khoshdel et al. 2016), non-small cell lung (Wang et al. 2021), and low-grade gliomas (Huang et al. 2021). The gene discussed is SERPINE1; the disease is cancer.