KCNK18 and migraine disorder: For example, in Aβ-RA + Aδ-LTMRs, Kcnq5 mediates M currents which have been linked to pain,56Kcnk18 (TRESK) a 2-pore potassium channel that has been described for its role in migraine as well as DRG hyperexcitability,82 and Kcnt1 (SLACK) has been described in the context of neuropathic pain after SNI.39 Most genes are either regulated in the same direction or only regulated in a subset of populations.