Of note, the metabolic and phagocytic deficits caused by TREM2 deficiency can also be reversed by cyclocreatine, an ATP analog (4), and by treatment with sodium rutin, a flavonoid that induces a switch from glycolysis to OXPHOS (3), raising the possibility that boosting microglial metabolic and energy homeostasis may be a potential therapeutic approach for AD treatment. This evidence concerns the gene TREM2 and Alzheimer disease.