SIRT2 knockdown or inhibition induces degradation of c-Myc protein in tumor cells by inducing its ubiquitination (45, 46), and treatment with FLS-359 for 72 hours dramatically reduced the level of the oncoprotein in MDA-MB-231 breast adenocarcinoma cells (Supplemental Figure 1B). This evidence concerns the gene SIRT2 and neoplasm.