Mutations in the KRAS and NRAS genes are frequently identified, with mutations in NRAS more frequent than mutations in KRAS, in myeloid disorders (15%–60%), including acute myeloid leukemia (AML), atypical chronic myeloid leukemia (aCML), CMML, and JMML (12). The gene discussed is KRAS; the disease is acute myeloid leukemia.