Of note, RAB27B depletion impacted the palmitoylation and PM localization of both WT and oncogenic NRAS, but more effectively suppressed oncogenic NRAS-mediated leukemia cell growth and ERK signaling, suggesting that oncogenic NRAS–conferred cell growth is more sensitive to inhibition of palmitoylation or ERK signaling. Here, NRAS is linked to leukemia.