Cohort studies showed that untreated patients with the Thr237Met and the Tyr254Cys mutations (ROSAH syndrome) had recurrent elevations of not only CRP (C reactive protein) but also of pro-inflammatory cytokines and chemokines, including TNF, IL-6, CCL2 (MCP-1), soluble IL-2 alpha receptor, and IL-10, CXCL10 (IP-10) in plasma and CXCL1 in serum (GRO-alpha). The gene discussed is CCL2; the disease is retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome.