ALPK1 and skin cancer: In addition to ALPK1 being involved in the progression of breast, lung, colorectal, oral, and skin cancers, as well as lymphoblastic leukemia, ALPK1 mutations are associated with gout, diabetes, and chronic kidney disease, which are thought to be related to breast, lung, colon, urinary tract, pancreas, and endometrium cancers, as well as lymphoblastic leukemia [89].