Accumulating data drives increases the recognition of the alpha-protein kinase 1 (ALPK1) as one of the master players in cellular processes [52,53] and also in the pathogenesis of cancer [54], recurrent periodic fever [55], ROSAH (retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache) syndrome [56], and type 2 diabetes mellitus [57]. The gene discussed is ALPK1; the disease is Splenomegaly.