IL-6, TNF-α, and IL-8 secretion was reduced by the cinnamon fraction in a dose-dependent manner. A cinnamon fraction may have anti-inflammatory properties by reducing LPS binding to monocytes. A natural PPAR-γ ligand may exist in the cinnamon fraction as well. A cinnamon fraction has been shown to contain anti-inflammatory properties that can be used to treat periodontal disease due to its anti-inflammatory properties. The gene discussed is TNF; the disease is periodontal disorder.