MMP8 and periodontitis: There was a statistically significant difference between G1 and G2 and G3 in the mean MMP-8 concentrations (p < 0.001). A statistically significant difference was not detected between G2 and G1 in the mean MMP-8 concentration. Licorice extract is a powerful natural remedy for periodontitis and inflammation, as well as preventing MMPs from being released by the host cells. There were no side effects associated with the use of licorice extract.