A comparison of the Th1/Th2-type cytokine profiles shows high concentrations of IFN-gamma, IL-2, and IL-4 in children with HBoV-related bronchiolitis [49] and in vitro stimulation of CD4 T cells with HboV1 virus-like particles (VLP) which increases the secretion of IFN-γ (Th1) and IL-10 and IL-13 (Th2). This evidence concerns the gene IFNG and bronchiolitis.