Similar to type 2 immune responses driving PC development in mouse models, patients with PC with a higher infiltration of Th1 (CD45+CD3+CD4+Tbet+) cells demonstrate a higher level of survival than those with predominantly TH2 (CD45+CD3+CD4+Gata3+)-polarized lymphoid cell infiltration [231]. This evidence concerns the gene PTPRC and pachyonychia congenita.