We have found one family with Molluscum lesions, pulmonary diseases and COPA deficiency; one patient with HPV lesions, monocytopenia and GATA2 deficiency and two families with HPV lesions, either EV or common warts, lymphopenia and STK4 deficiency. The gene discussed is STK4; the disease is hyperinsulinemic hypoglycemia, familial, 4.