The prevention of T2DM was induced with a high-fat diet in the C57BL/6J mouse using two hydro-alcoholic extracts of A. herba alba Asso (AHA) and Centaurium erythraea Rafn (CE), which are used in the traditional treatment of diabetes in Algeria [80], as plant extracts considerably reduce insulin resistance. The gene discussed is INS; the disease is diabetes mellitus.