Recently, Liu et al. found, in a mouse model, the pathogenetic mechanism of HP associated with GP; the bacterial infection led to a reduction in the number of Interstitial Cajal Cells (ICCs) and alteration of the ICC network due to a decrease in the level of Stem Cell Factor (SCF), a protein known to activate the proliferation and function of ICCs through the activation of the c-kit receptors [125]. The gene discussed is KITLG; the disease is bacterial infectious disease.