Elevated MRproADM concentrations correlate with clinical scores of severity in ICU patients, such as sepsis-related organ failure assessment (SOFA), and acute physiology and chronic health evaluation score (APACHE), and inflammatory biomarkers, such as C reactive protein (CRP), IL-6, IL-10, procalcitonin (PCT), and TNFα [97]. This evidence concerns the gene CRP and Sepsis.