ZFP57 and metabolic dysfunction-associated steatotic liver disease: E. siraeum has previously been linked to NAFLD, and in non-human primates its abundance was positively correlated with high-density lipoprotein cholesterol levels.25,26 In our study, we observed an inverse correlation between changes in E. siraeum abundance and methylation of cg16885113 in ZFP57, further discussed below.