HDAC7 and obesity due to melanocortin 4 receptor deficiency: Differences in methylation of genes involved in glucose and energy homeostasis were accompanied by different levels of expression, e.g. in Histone deacetylase 7 gene (HDAC7) and Insulin – like growth factor protein gene (IGF2BP2).16 Guo et al. have demonstrated that obesity-prone individuals exhibit diabetes-related DNA methylation signatures despite being normal in weight and BMI.