Reversely, hepatoma cells (Huh‐7 and SNU‐423) with HCV core expression presented with significantly suppressed cell proliferation activity ((Huh 7 (69%) and SNU‐423(83%)) of activated splenic CD8+ cells by anti‐CD3 antibody compared with GFP expression alone ((Huh 7 (58%) and SNU‐423(53%)) (Figure 6e,f). Here, CD8A is linked to hepatocellular carcinoma.