Activated spleen CD8+ cells by anti‐CD3 antibody significantly inhibited the levels of kynurenine (85%) and PD‐L1 (92%) in hepatoma cells transfected with an ISX‐specific shRNAi construct compared with that of hepatoma cells treated with GFP along (Figure 6c,d). This evidence concerns the gene CD274 and hepatocellular carcinoma.