NFKB1 and hepatocellular carcinoma: The HCV core protein has been shown to activate NF‐κB (p65) signals by interacting with tumor necrosis factor receptor‐associated factors involved in HCC progression.[19] In the current study, the HCV core‐NF‐κB signals have been shown to further transactivate ISX levels via the cis regulation of NF‐κB (p65) on the ISX promoter element to initiate consequent pathologic progression.