CD8A and hepatocellular carcinoma: Hepatoma cells (Huh‐7 and SNU‐423) cotransfected with HCV core and ISX‐specific shRNAi had a minor suppression in the cell proliferation activity ((Huh 7 (33%) and SNU‐423(34%)) of activated splenic CD8+ cells by anti‐CD3 antibody compared with that of GFP expression alone (Figure 6e,f).