SEMA3D and Mental deterioration: The Y-maze test was carried out on the 4th day after each ICV injection to measure the sequential changes in spatial working memory, with the result of one-way repeated measures ANOVA showing that mice with chronic increase of Sema3D exhibited time-dependent cognitive decline (p = 0.014, Fig. 2F) and post-hoc analysis illustrating significant cognitive decline by week 8 (an adjusted p value of 0.032) and more deterioration by week 10 (an adjusted p value of 0.016).