After age, gender, BMI, smoking, alcohol consumption, diabetes mellitus, hypertension, TC, TG, Apo (a), fasting blood glucose levels, and LDL-C were adjusted, the expression of hsa_circRPRD1A (OR = 0.613, 95%CI:0.380–0.987, P = 0.044) remained significantly associated with CAD prevalence. The gene discussed is AOPEP; the disease is hypertensive disorder.