HCST and neoplasm: Compared to either hnCD16 or FR2 (hnCD16-DAP10-CD3ζ) and FR3 (hnCD16-2B4-FcεRIγ), FR1 (hnCD16-2B4-DAP10-CD3ζ) could mediate significantly superior ADCC effects in different tissue-derived tumor cell lines.