We observed that upon stimulation with tumor cells or tumor cells plus Obinutuzumab, the secretion of IFN-γ, Granzyme B, Perforin, Granulysin, and IL-10 was significantly increased in NK cells expressing hnCD16FR (Fig. 4A–E), whereas Granzyme A was secreted at high levels only in NK cells expressing hnCD16 (Fig. 4F). Here, PRF1 is linked to neoplasm.