The finding of a low fraction of high-risk non-BRCA1/BRCA2 familial breast cancers with high HRDetect scores is noteworthy, as one might expect non-BRCA1/BRCA2 high-risk familial breast tumours to have a higher frequency of high HRDetect scores similar to tumours from families with mutations in these high-penetrant genes. This evidence concerns the gene BRCA1 and breast neoplasm.