The EGFR pathway can be activated to cause VEGF production and VEGFR activity, to promote angiogenesis through upregulation of hypoxia-dependent HIF-α expression [8], while the EFGR-TKIs directly suppresses tumor growth via preventing the EGFR pathway, and block the VEGF to inhibit angiogenesis. The gene discussed is VEGFA; the disease is neoplasm.