Except for the no significant statistical difference in abnormal ALT/AST group on both treatments (P=0.67), the incidences of rash[HR:1.44 (95%CI:1.01-2.05, P=0.05)], diarrhea[HR:2.71 (95%CI:1.41-5.19, P=0.003)], proteinuria[HR:10.59(95%CI: 4.23-26.51, P<0.00001)] and hypertension[HR:1.08 (95%CI: 0.77-1.50, P<0.00001)] on using angiogenesis inhibitors in conjunction with EGFR-TKIs group are all higher than the EGFR-TKIs only group. Here, EGFR is linked to Hypertension.