LEP and Insulin resistance: Nuts and coffee are rich in vitamin E, vitamin B3, potassium, magnesium, fiber, unsaturated fatty acids, polyphenols, phytosterols, etc., which may have a protective role in T2D risk through mediating the inflammation and oxidative status, regulatory effect on adiponectin and leptin levels, improving endothelial function, reducing plasma triglycerides and insulin resistance [30, 32, 33, 41].