TNF and synovial sarcoma: Furthermore, the infiltration of inflammatory cytokine (such as IL-6, IL-17, and TNF-α)-producing cells into the salivary gland was decreased by L. acidophilus (Fig. 2C), and infiltration of Th1, Th2, Th17, and B17 cells into salivary gland and spleen was also decreased by L. acidophilus (Fig. 2D, E), whereas Treg cells were increased by L. acidophilus. Our results show that L. acidophilus has immunomodulatory (anti-inflammatory) effects in SS.