Increased heme oxygenase 1 (HO-1) messenger RNA expression and upregulated HO-1 protein levels were observed in PCa cell lines DU 145 and PC3 [21], implying that HO-1 may play a role in the development of PCa for its function in promoting angiogenesis [22]. The gene discussed is HMOX1; the disease is posterior cortical atrophy.