Metal ion and heat synergistically contributed to cell oxidative stress, which stimulated receptor patterns to assemble and activate the Nlrp3 inflammasome, the inflammasome can further activate the caspase 1 to induce the cleavage of gasdermin D. EGCG further increased oxidative stress by inhibiting heat stress resistance, consequently, tumor cells accumulated much cell stress that caused cell pyroptosis. Here, GSDMD is linked to neoplasm.