CASP1 and neoplasm: Metal ion and heat synergistically contributed to cell oxidative stress, which stimulated receptor patterns to assemble and activate the Nlrp3 inflammasome, the inflammasome can further activate the caspase 1 to induce the cleavage of gasdermin D. EGCG further increased oxidative stress by inhibiting heat stress resistance, consequently, tumor cells accumulated much cell stress that caused cell pyroptosis.