Evaluation for immunodeficiencies included a negative HIV-1/2 antibody/antigen screen, undetectable HIV RNA viral load, CD4 + T cells of 700 cell/mm3 (500-1,200), CD4/CD8 ratio > 1, normal S. pneumoniae and tetanus toxoid Ab titers, and quantitative immunoglobulins. The gene discussed is CD4; the disease is immunodeficiency disease.