VEGF induces the activation of proteins such as urokinase, tissue-type plasminogen activator, plasminogen activator inhibitor-1 and matrix metalloproteinases, and binds toVEGFR1 andVEGFR2, which are predominantly expressed on the cell surface of several anti-apoptotic factors that promote tumor growth and tumor metastasis. The gene discussed is SERPINE1; the disease is neoplasm.